GABAergic Mechanisms in Epilepsy

GABAergic Dysfunction in Autism and Epilepsy

GABAergic mechanisms in morphine analgesia.

There are coflicting reports regarding the role of GABA in morphine analgesia. While-sorne investigators have reported that treatment with GABAA receptor agonist muscimol and GABA transaminase inhibitors potentiates morphine analgesia (2.4.6) others have reported antagonism of morphine analgesia (8.10). In view of these conflicting reports and since the analgesic profile 'of THIP, a GABAA recep...

Purinergic mechanisms in epilepsy.

Adenosine is a powerful neuromodulator that has a range of functions in various cells and tissues throughout the body. In the brain adenosine controls many varied processes through a range of receptors. Research over the past 25 years has implicated adenosine, acting predominantly through the A1 receptor, in seizure control and epilepsy. Most of this work has utilized animal models and there ar...

Mechanisms of GABAergic Homeostatic Plasticity

Homeostatic plasticity ensures that appropriate levels of activity are maintained through compensatory adjustments in synaptic strength and cellular excitability. For instance, excitatory glutamatergic synapses are strengthened following activity blockade and weakened following increases in spiking activity. This form of plasticity has been described in a wide array of networks at several diffe...

GABAergic Synapse Dysfunction and Repair in Temporal Lobe Epilepsy

Severe medial temporal lobe epilepsy (mTLE) is often associated with pharmacoresistant seizures, impaired memory and mood disorders. In the hippocampus, GABAergic inhibitory interneuron dysfunction and other neural circuit abnormalities contribute to hyperexcitability, but the mechanisms are still not well understood. Experimental approaches aimed at correcting deficits in hippocampal circuits ...